VDJdb: a curated database of T-cell receptor sequences with known antigen specificity
Privolzhsky Research Medical University · Skolkovo Institute of Science and Technology · +12 more institutions
Abstract
The ability to decode antigen specificities encapsulated in the sequences of rearranged T-cell receptor (TCR) genes is critical for our understanding of the adaptive immune system and promises significant advances in the field of translational medicine. Recent developments in high-throughput sequencing methods (immune repertoire sequencing technology, or RepSeq) and single-cell RNA sequencing technology have allowed us to obtain huge numbers of TCR sequences from donor samples and link them to T-cell phenotypes. However, our ability to annotate these TCR sequences still lags behind, owing to the enormous diversity of the TCR repertoire and the scarcity of available data on T-cell specificities. In this paper,…
Citation impact
- FWCI
- 16.15
- Percentile
- 100%
- References
- 24
Authors
28- MSMikhail Shugay
Privolzhsky Research Medical University, Skolkovo Institute of Science and Technology, Central European Institute of Technology, Pirogov Russian National Research Medical University, Institute of Bioorganic Chemistry
- DVDmitriy V. Bagaev
Institute of Bioorganic Chemistry
- IVIvan V. Zvyagin
Pirogov Russian National Research Medical University, Institute of Bioorganic Chemistry
- RMRenske M. A. Vroomans
Utrecht University
- JCJeremy Chase Crawford
St. Jude Children's Research Hospital
Topics & keywords
- T-cell receptor
- Biology
- Repertoire
- Annotation
- Antigen
- Computational biology
- Genetics
- Gene
Funding
- CRCancer Research Wales
- WTWellcome Trust
- ANAnthony Nolan
- ECEuropean CommissionAward: 633592
- CECentral European Institute of TechnologyAward: LQ1601
- SISkolkovo Institute of Science and Technology
- PRPirogov Russian National Research Medical University
- DFDirectorate for Biological Sciences
- MRMedical Research Council
- NHNational Health and Medical Research CouncilAward: APP613664