Form Follows Function: Nanoparticle Shape and Its Implications for Nanomedicine

This review is a comprehensive description of the past decade of research into understanding how the geometry and size of nanoparticles affect their interaction with biological systems: from single cells to whole organisms. Recently, there has been a great deal of effort to use both the shape and the size of nanoparticles to target specific cellular uptake mechanisms, biodistribution patterns, and pharmacokinetics. While the successes of spherical lipid-based nanoparticles have heralded marked changes in chemotherapy worldwide, the history of asbestos-induced lung disease casts a long shadow over fibrous materials to date. The impact of particle morphology is known to be intertwined with many physicochemical…

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  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

  Award: PP00P2_123373
• AM
  Adolphe Merkle Foundation