An immune clock of human pregnancy

Aghaeepour, Nima; Ganio, Edward A.; McIlwain, David R.; Tsai, Amy S.; Tingle, Martha; Gassen, Sofie Van; Gaudillière, Dyani; Baca, Quentin; McNeil, Leslie; Okada, Robin L.; Ghaemi, Mohammad Sajjad; Furman, David; Wong, Ronald J.; Winn, Virginia D.; Druzin, Maurice L.; El-Sayed, Yaser Y.; Quaintance, Cecele C.; Gibbs, Ronald S.; Darmstadt, Gary L.; Shaw, Gary M.; Stevenson, David K.; Tibshirani, Robert; Nolan, Garry P.; Lewis, David B.; Angst, Martin S.; Gaudillière, Brice

doi:10.1126/sciimmunol.aan2946

articleScience ImmunologySep 1, 2017HYBRID OA

An immune clock of human pregnancy

NANima Aghaeepour EAEdward A. Ganio DRDavid R. McIlwain ASAmy S. Tsai MTMartha Tingle

Stanford Medicine · Stanford University · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

The maintenance of pregnancy relies on finely tuned immune adaptations. We demonstrate that these adaptations are precisely timed, reflecting an immune clock of pregnancy in women delivering at term. Using mass cytometry, the abundance and functional responses of all major immune cell subsets were quantified in serial blood samples collected throughout pregnancy. Cell signaling-based Elastic Net, a regularized regression method adapted from the elastic net algorithm, was developed to infer and prospectively validate a predictive model of interrelated immune events that accurately captures the chronology of pregnancy. Model components highlighted existing knowledge and revealed previously unreported biology,…

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514

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Topics & keywords

Topics

Keywords

Pregnancy
Immune system
Biology
Mass cytometry
Immunology
Computational biology
Bioinformatics
Phenotype

UN Sustainable Development Goals

Good health and well-being

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