Progress and prospects of early detection in lung cancer
North Manchester General Hospital · Cancer Research UK · +5 more institutions
Abstract
Lung cancer is the leading cause of cancer-related death in the world. It is broadly divided into small cell (SCLC, approx. 15% cases) and non-small cell lung cancer (NSCLC, approx. 85% cases). The main histological subtypes of NSCLC are adenocarcinoma and squamous cell carcinoma, with the presence of specific DNA mutations allowing further molecular stratification. If identified at an early stage, surgical resection of NSCLC offers a favourable prognosis, with published case series reporting 5-year survival rates of up to 70% for small, localized tumours (stage I). However, most patients (approx. 75%) have advanced disease at the time of diagnosis (stage III/IV) and despite significant developments in the…
Citation impact
- FWCI
- 46.15
- Percentile
- 100%
- References
- 162
Authors
6- SKSean Knight
North Manchester General Hospital
- PCPhilip Crosbie
Cancer Research UK, North Manchester General Hospital, CRUK Lung Cancer Centre of Excellence, University College London
- HBHaval Balata
North Manchester General Hospital
- JCJakub Chudziak
University of Manchester, Cancer Research UK Manchester Institute
- THTracy Hussell
University of Manchester, Centre for Inflammation Research
Topics & keywords
- Lung cancer
- Biology
- Stage (stratigraphy)
- Adenocarcinoma
- Cancer
- Oncology
- Internal medicine
- Survival rate