The Clinical Potential of Senolytic Drugs
Mayo Clinic in Florida · Scripps Research Institute
Abstract
Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases. In studies in animals, targeting senescent cells using genetic or pharmacological approaches delays, prevents, or alleviates multiple age-related phenotypes, chronic diseases, geriatric syndromes, and loss of physiological resilience. Among the chronic conditions successfully treated by depleting senescent cells in preclinical studies are frailty, cardiac dysfunction, vascular hyporeactivity and calcification, diabetes mellitus, liver steatosis, osteoporosis, vertebral disk degeneration, pulmonary fibrosis, and…
Citation impact
- FWCI
- 36.83
- Percentile
- 100%
- References
- 48
Authors
5Topics & keywords
- Medicine
- Clinical trial
- Diabetes mellitus
- Steatosis
- Osteoporosis
- Fibrosis
- Bioinformatics
- Inflammation