The RNA modification landscape in human disease

RNA modifications have been historically considered as fine-tuning chemo-structural features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has changed dramatically in recent years, to a large extent as a result of systematic efforts to map and quantify various RNA modifications in a transcriptome-wide manner, revealing that RNA modifications are reversible, dynamically regulated, far more widespread than originally thought, and involved in major biological processes, including cell differentiation, sex determination, and stress responses. Here we summarize the state of knowledge and provide a catalog of RNA modifications and their links to neurological disorders, cancers, and other…

• HF
  Human Frontier Science Program

  Award: LT000307/2013-L
• UO
  University of New South Wales
• MR
  Medical Research Council
• AR
  Australian Research Council

  Award: DE170100506
• NH
  National Health and Medical Research Council

  Award: APP1070631
• CC
  Cancer Council NSW

  Award: RG 14-18