Intestinal barrier and gut microbiota: Shaping our immune responses throughout life

The gastrointestinal (GI) tract is considered the largest immunological organ in the body having a central role in regulating immune homeostasis. Contrary to earlier belief, the intestinal epithelial barrier is not a static physical barrier but rather strongly interacts with the gut microbiome and cells of the immune system. This intense communication between epithelial cells, immune cells and microbiome will shape specific immune responses to antigens, balancing tolerance and effector immune functions. Recent studies indicate that composition of the gut microbiome affects immune system development and modulates immune mediators, which in turn affect the intestinal barrier. Moreover, dysbiosis may favor…

• FD
  Fundação de Amparo à Pesquisa do Estado de São Paulo
• CD
  Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
• UD
  Universidade de São Paulo