Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians
University of Toronto · Hospital for Sick Children · +8 more institutions
Abstract
There are numerous reference equations available for the single-breath transfer factor of the lung for carbon monoxide ( T LCO ); however, it is not always clear which reference set should be used in clinical practice. The aim of the study was to develop the Global Lung Function Initiative (GLI) all-age reference values for T LCO . Data from 19 centres in 14 countries were collected to define T LCO reference values. Similar to the GLI spirometry project, reference values were derived using the LMS (lambda, mu, sigma) method and the GAMLSS (generalised additive models for location, scale and shape) programme in R. 12 660 T LCO measurements from asymptomatic, lifetime nonsmokers were submitted; 85% of the…
Citation impact
- FWCI
- 24.82
- Percentile
- 100%
- References
- 41
Authors
7- SSSanja StanojevicCorresponding
University of Toronto, Hospital for Sick Children, SickKids Foundation
- BLBrian L. Graham
University of Saskatchewan
- BCBrendan Cooper
University Hospitals Birmingham NHS Foundation Trust
- BTBruce Thompson
The Alfred Hospital, Monash University
- KWKim W. Carter
The Kids Research Institute Australia, The University of Western Australia
Topics & keywords
- Medicine
- Reference values
- Statistics
- Transfer factor
- Lung function
- Carbon monoxide
- Spirometry
- Lung volumes
- Life below water