Cardiac troponins: from myocardial infarction to chronic disease
King's College London · University of Oxford · +3 more institutions
Abstract
Elucidation of the physiologically distinct subunits of troponin in 1973 greatly facilitated our understanding of cardiac contraction. Although troponins are expressed in both skeletal and cardiac muscle, there are isoforms of troponin I/T expressed selectively in the heart. By exploiting cardiac-restricted epitopes within these proteins, one of the most successful diagnostic tests to date has been developed: cardiac troponin (cTn) assays. For the past decade, cTn has been regarded as the gold-standard marker for acute myocardial necrosis: the pathological hallmark of acute myocardial infarction (AMI). Whilst cTn is the cornerstone for ruling-out AMI in patients presenting with a suspected acute coronary…
Citation impact
- FWCI
- 24.50
- Percentile
- 100%
- References
- 106
Authors
4- KCKyung Chan Park
King's College London, University of Oxford
- DGDavid Gaze
St George's, University of London, St George’s University Hospitals NHS Foundation Trust, University of Westminster
- PCPaul Collinson
St George's, University of London, St George’s University Hospitals NHS Foundation Trust
- MMMichael MarberCorresponding
King's College London
Topics & keywords
- Myocardial infarction
- Cardiology
- Medicine
- Internal medicine
- Troponin
- Good health and well-being