A novel microglial subset plays a key role in myelinogenesis in developing brain
University of Southern Denmark · University Medical Center Groningen · +7 more institutions
Abstract
Abstract Microglia are resident macrophages of the central nervous system that contribute to homeostasis and neuroinflammation. Although known to play an important role in brain development, their exact function has not been fully described. Here, we show that in contrast to healthy adult and inflammation‐activated cells, neonatal microglia show a unique myelinogenic and neurogenic phenotype. A CD11c + microglial subset that predominates in primary myelinating areas of the developing brain expresses genes for neuronal and glial survival, migration, and differentiation. These cells are the major source of insulin‐like growth factor 1, and its selective depletion from CD11c + microglia leads to impairment of…
Citation impact
- FWCI
- 21.41
- Percentile
- 100%
- References
- 58
Authors
15- AWAgnieszka WłodarczykCorresponding
University of Southern Denmark
- IRInge R. Holtman
University Medical Center Groningen, University of Groningen
- MKMartin Krueger
Leipzig University
- NYNir Yogev
Johannes Gutenberg University Mainz, University Medical Center of the Johannes Gutenberg University Mainz
- JBJulia Bruttger
Johannes Gutenberg University Mainz, University Medical Center of the Johannes Gutenberg University Mainz
Topics & keywords
- Biology
- Myelinogenesis
- Key (lock)
- Neuroscience
- Cell biology
- Computational biology
- Myelin sheath
- Central nervous system