The Role of Sirtuins in Antioxidant and Redox Signaling

SIGNIFICANCE: Antioxidant and redox signaling (ARS) events are regulated by critical molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen species (RNS), and/or oxidative stress within the cell. Imbalances in these molecules can disturb cellular functions to become pathogenic. Sirtuins serve as important regulators of ARS in cells. Recent Advances: Sirtuins (SIRTs 1-7) are a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases with the ability to deacetylate histone and nonhistone targets. Recent studies show that sirtuins modulate the regulation of a variety of cellular processes associated with ARS. SIRT1, SIRT3, and SIRT5 protect the cell from…

• UD
  U.S. Department of Veterans Affairs

  Awards: I01CX001441, IK6BX003780, I01BX001008
• NI
  National Institutes of Health

  Awards: R01AR059130, R01AR059130 and R01CA176748, R01CA176748