Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

Geller, Leore T.; Barzily-Rokni, Michal; Danino, Tal; Jonas, Oliver; Shental, Noam; Nejman, Deborah; Gavert, Nancy; Zwang, Yaara; Cooper, Zachary A.; Shee, Kevin; Thaiss, Christoph A.; Reuben, Alexandre; Livny, Jonathan; Avraham, Roi; Frederick, Dennie T.; Ligorio, Matteo; Chatman, Kelly; Johnston, Stephen; Mosher, Carrie M.; Brandis, Alexander; Fuks, Garold; Gurbatri, Candice R.; Gopalakrishnan, Vancheswaran; Kim, Michael P.; Hurd, Mark W.; Katz, Matthew H. G.; Fleming, Jason B.; Maitra, Anirban; Smith, David A.; Skalak, Matt; Bu, Jeffrey; Michaud, Monia; Trauger, Sunia A.; Barshack, Iris; Golan, Talia; Sandbank, Judith; Flaherty, Keith T.; Mandinova, Anna; Garrett, Wendy S.; Thayer, Sarah P.; Ferrone, Cristina R.; Huttenhower, Curtis; Bhatia, Sangeeta N.; Gevers, Dirk; Wargo, Jennifer A.; Golub, Todd R.; Straussman, Ravid

doi:10.1126/science.aah5043

articleScienceSep 14, 2017GREEN OA

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

LTLeore T. Geller MBMichal Barzily-Rokni TDTal Danino OJOliver Jonas NSNoam Shental

Weizmann Institute of Science · Broad Institute · +16 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Expression, and abrogated by cotreatment with the antibiotic ciprofloxacin. Gemcitabine is commonly used to treat pancreatic ductal adenocarcinoma (PDAC), and we hypothesized that intratumor bacteria might contribute to drug resistance of these tumors. Consistent with this possibility, we found that of the 113 human PDACs that were tested, 86 (76%) were positive for bacteria, mainly Gammaproteobacteria.

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Topics & keywords

Topics

Keywords

Gemcitabine
Drug resistance
Drug
Bacteria
Chemotherapeutic drugs
Cancer research
Biology
Pharmacology

UN Sustainable Development Goals

Good health and well-being

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