Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping

Breast cancer cell lines have been widely used for breast cancer modelling which encompasses a panel of diseases with distinct phenotypical associations. Though cell lines provide unlimited homogenous materials for tumor studies and are relatively easy to culture, they are known to accumulate mutations duringthe initial establishment and subsequent series of cultivations. Thus, whether breast cancer cell line heterogeneity reflects that of carcinoma remains an important issue to resolve before drawing any reliable conclusion at the tumor level using cell lines. Inconsistent nomenclatures used for breast cancer cell line subtyping and the different number of subtypes grouped for cell lines and tumors make their…

• NN
  National Natural Science Foundation of China

  Awards: 31471251, BK20161130, SWYY-128
• GO
  Government of Jiangsu Province

  Award: SWYY-128
• NS
  Natural Science Foundation of Jiangsu Province

  Awards: 31471251, BK20161130
• ST
  Six Talent Peaks Project in Jiangsu Province

  Awards: SWYY-128, BK20161130
• FR
  Fundamental Research Funds for the Central Universities

  Award: JUSRP11507