Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

Bertrand, Nicolas; Grenier, P.; Mahmoudi, Morteza; Lima, Eliana Martins; Appel, Eric A.; Dormont, Flavio; Lim, Jong‐Min; Karnik, Rohit; Langer, Róbert; Farokhzad, Omid C.

doi:10.1038/s41467-017-00600-w

articleNature CommunicationsSep 27, 2017GOLD OA

Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

NBNicolas Bertrand PGP. Grenier MMMorteza Mahmoudi EMEliana Martins Lima EAEric A. Appel

Université Laval · Massachusetts Institute of Technology · +8 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Abstract In vitro incubation of nanomaterials with plasma offer insights on biological interactions, but cannot fully explain the in vivo fate of nanomaterials. Here, we use a library of polymer nanoparticles to show how physicochemical characteristics influence blood circulation and early distribution. For particles with different diameters, surface hydrophilicity appears to mediate early clearance. Densities above a critical value of approximately 20 poly(ethylene glycol) chains (MW 5 kDa) per 100 nm 2 prolong circulation times, irrespective of size. In knockout mice, clearance mechanisms are identified for nanoparticles with low and high steric protection. Studies in animals deficient in the C3 protein…

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674

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References: 51

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Topics & keywords

Topics

Keywords

Ethylene glycol
Nanoparticle
In vivo
Biophysics
Chemistry
Nanomaterials
Nanotechnology
Biodistribution

UN Sustainable Development Goals

Good health and well-being

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