Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
Délégation Paris 5 · Inserm · +4 more institutions
Abstract
The cushioning function of large arteries encompasses distension during systole and recoil during diastole which transforms pulsatile flow into a steady flow in the microcirculation. Arterial stiffness, the inverse of distensibility, has been implicated in various etiologies of chronic common and monogenic cardiovascular diseases and is a major cause of morbidity and mortality globally. The first components that contribute to arterial stiffening are extracellular matrix (ECM) proteins that support the mechanical load, while the second important components are vascular smooth muscle cells (VSMCs), which not only regulate actomyosin interactions for contraction but mediate also mechanotransduction in cell-ECM…
Citation impact
- FWCI
- 34.48
- Percentile
- 100%
- References
- 606
Authors
4- PLPatrick LacolleyCorresponding
Délégation Paris 5, Inserm, Université Paris Cité, Assistance Publique – Hôpitaux de Paris, Paris Cardiovascular Research Center, Université de Lorraine
- VRVéronique Regnault
Délégation Paris 5, Inserm, Université Paris Cité, Assistance Publique – Hôpitaux de Paris, Paris Cardiovascular Research Center, Université de Lorraine
- PSPatrick Segers
Délégation Paris 5, Inserm, Université Paris Cité, Assistance Publique – Hôpitaux de Paris, Paris Cardiovascular Research Center, Université de Lorraine
- SLStéphane Laurent
Délégation Paris 5, Inserm, Université Paris Cité, Assistance Publique – Hôpitaux de Paris, Paris Cardiovascular Research Center, Université de Lorraine
Topics & keywords
- Mechanotransduction
- Arterial stiffness
- Arteriogenesis
- Vascular smooth muscle
- Internal medicine
- Microcirculation
- Extracellular matrix
- Biology
- Good health and well-being