Revisiting biomarker discovery by plasma proteomics
University of Copenhagen · Max Planck Institute of Biochemistry · +2 more institutions
Abstract
Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support treatment decisions. However, existing biomarkers are far from comprehensive and often lack specificity and new ones are being developed at a very slow rate. As described in this review, mass spectrometry (MS)-based proteomics has become a powerful technology in biological research and it is now poised to allow the characterization of the plasma proteome in great depth. Previous "triangular strategies" aimed at discovering single biomarker candidates in small cohorts, followed by classical immunoassays in much larger validation cohorts. We propose a…
Citation impact
- FWCI
- 34.58
- Percentile
- 100%
- References
- 98
Authors
4- PEPhilipp E. GeyerCorresponding
University of Copenhagen, Max Planck Institute of Biochemistry
- LMLesca M. Holdt
LMU Klinikum, Ludwig-Maximilians-Universität München
- DTDaniel Teupser
LMU Klinikum, Ludwig-Maximilians-Universität München
- MMMatthias Mann
University of Copenhagen, Max Planck Institute of Biochemistry
Topics & keywords
- Proteome
- Proteomics
- Biomarker discovery
- Computational biology
- Biomarker
- Biology
- Profiling (computer programming)
- Bioinformatics
- Peace, Justice and strong institutions