Gut microbiome alterations in Alzheimer’s disease

Alzheimer's disease (AD) is the most common form of dementia. However, the etiopathogenesis of this devastating disease is not fully understood. Recent studies in rodents suggest that alterations in the gut microbiome may contribute to amyloid deposition, yet the microbial communities associated with AD have not been characterized in humans. Towards this end, we characterized the bacterial taxonomic composition of fecal samples from participants with and without a diagnosis of dementia due to AD. Our analyses revealed that the gut microbiome of AD participants has decreased microbial diversity and is compositionally distinct from control age- and sex-matched individuals. We identified phylum- through…

• AA
  Alzheimer's Association

  Awards: R01 AG027161, R01 AG037639, R01 AG021155
• TS
  Torsten Söderbergs Stiftelse
• RU
  Rush University
• GC
  Georgia Clinical and Translational Science Alliance
• RS
  Royal Swedish Academy of Sciences
• V
  Vetenskapsrådet
• NI
  National Institutes of Health

  Awards: R01 AG027161, AG037639, NIH P50 AG033514, R01 AG037639, P50 AG033514, AG027161, UL1TR000427, AG021155, NIH P50, R01 AG021155, AG033514
• IF
  Institute for Clinical and Translational Research, University of Wisconsin, Madison

  Award: UL1TR000427
• NC
  National Center for Advancing Translational Sciences

  Award: UL1TR000427