The gut microbiome in atherosclerotic cardiovascular disease

The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular health. Although drug treatment represents a confounding factor, ACVD status, and not current drug use, is…

• NN
  National Natural Science Foundation of China

  Awards: 81373486, 81673514
• GO
  Government of Jiangxi Province
• FP
  Fundo para o Desenvolvimento das Ciências e da Tecnologia
• NK
  National Key Research and Development Program of China