Ligand-Promoted Palladium-Catalyzed Aerobic Oxidation Reactions

Palladium-catalyzed aerobic oxidation reactions have been the focus of industrial application and extensive research efforts for nearly 60 years. A significant transition occurred in this field approximately 20 years ago, with the introduction of catalysts supported by ancillary ligands. The ligands play crucial roles in the reactions, including promotion of direct oxidation of palladium(0) by O2, bypassing the typical requirement for Cu salts or related redox cocatalysts to facilitate oxidation of the reduced Pd catalyst; facilitation of key bond-breaking and bond-forming steps during substrate oxidation; and modulation of chemo-, regio-, or stereoselectivity of a reaction. The use of ligands has contributed…

• CF
  Center for Selective C-H Functionalization, National Science Foundation

  Award: CHE-1205646
• NI
  National Institute of General Medical Sciences

  Award: R01 GM67173
• DO
  Division of Chemistry

  Award: CHE-1665120