TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis
Sechenov University · Bioinformatics Institute · +3 more institutions
Abstract
Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate immune response and its activation by bacterial endotoxin is responsible for chronic and acute inflammatory disorders that are becoming more and more frequent in developed countries. Modulation of the TLR4 pathway is a potential strategy to specifically target these pathologies. Among the diseases caused by TLR4 abnormal activation by bacterial endotoxin, sepsis is the most dangerous one because it is a life-threatening acute system inflammatory condition that still lacks specific pharmacological treatment. Here, we review molecules at a preclinical or clinical phase of development, that are active in inhibiting the…
Citation impact
- FWCI
- 16.60
- Percentile
- 100%
- References
- 193
Authors
6- NKNikolay KuzmichCorresponding
Sechenov University, Bioinformatics Institute, Research Institute of Influenza
- КВК. В. Сивак
Research Institute of Influenza
- VNVladimir N. Chubarev
Sechenov University
- YBYuri B. Porozov
ITMO University, Sechenov University, Bioinformatics Institute
- TNT. N. Savateeva-Lyubimova
Research Institute of Influenza
Topics & keywords
- TLR4
- Inflammation
- Sepsis
- Innate immune system
- TRIF
- Toll-like receptor
- Signal transduction
- Medicine
- Partnerships for the goals