articleScienceOct 6, 2017GREEN OA

A high-coverage Neandertal genome from Vindija Cave in Croatia

KPKay PrüferCDCesare de FilippoSGSteffi GroteFMFabrizio MafessoniPKPetra Korlević

Max Planck Institute for Evolutionary Anthropology · Aarhus University · +10 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

To date, the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from ~50,000 years ago from Vindija Cave, Croatia, to ~30-fold genomic coverage. She carried 1.6 differences per 10,000 base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10 to 20% more Neandertal DNA to be identified in…

Citation impact

770
total citations
FWCI
373.31
Percentile
100%
References
113
Citations per year

Authors

36

Topics & keywords

Topics
Keywords
  • Genome
  • Biology
  • Cave
  • Evolutionary biology
  • Genetics
  • Gene
  • Ecology
No related works found for this paper.

Funding