Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer’s disease
University of California, San Francisco · University Memory and Aging Center · +2 more institutions
Abstract
Neuropathological and in vivo studies have revealed a tight relationship between tau pathology and cognitive impairment across the Alzheimer's disease spectrum. However, tau pathology is also intimately associated with neurodegeneration and amyloid pathology. The aim of the present study was therefore to assess whether grey matter atrophy and amyloid pathology contribute to the relationship between tau pathology, as measured with 18F-AV-1451-PET imaging, and cognitive deficits in Alzheimer's disease. We included 40 amyloid-positive patients meeting criteria for mild cognitive impairment due to Alzheimer's disease (n = 5) or probable Alzheimer's disease dementia (n = 35). Twelve patients additionally fulfilled…
Citation impact
- FWCI
- 31.95
- Percentile
- 100%
- References
- 55
Authors
17- ABAlexandre BejaninCorresponding
University of California, San Francisco, University Memory and Aging Center
- DRDaniel R. Schonhaut
University of California, San Francisco, University Memory and Aging Center
- RLRenaud La Joie
University of California, San Francisco, University Memory and Aging Center
- JHJoel H. Kramer
University of California, San Francisco, University Memory and Aging Center
- SLSuzanne L. Baker
Lawrence Berkeley National Laboratory
Topics & keywords
- Neurodegeneration
- Neuroscience
- Cognitive impairment
- Alzheimer's disease
- Disease
- Tau pathology
- Medicine
- Cognition
- Quality Education