Critical Overview of the Use of Ru(II) Polypyridyl Complexes as Photosensitizers in One-Photon and Two-Photon Photodynamic Therapy

ConspectusPhotodynamic Therapy (PDT) is an emerging technique to treat certain types of cancer, bacterial, fungal, and viral infections, and skin diseases. In past years, different research groups developed new ruthenium-containing photosensitizers (PSs) with tuned photophysical and biological properties to better fit the requirements of PDT. In this Account, we report and discuss the latest results in this research area, emphasizing particularly our own research. For example, inspired by the DNA intercalating complex [Ru(bpy)2(dppz)]2+ (bpy = 2,2′-bipyridine; dppz = (dipyrido[3,2-a:2′,3′-c]phenazine), a series of ruthenium complexes bearing differently functionalized dppz ligands were synthesized to target…

• AN
  Agence Nationale de la Recherche

  Award: ANR-10-IDEX-0001-02 PSL
• HE
  H2020 European Research Council

  Award: GA 681679