Association analysis identifies 65 new breast cancer risk loci
University of Cambridge · Cyprus Institute of Neurology and Genetics · +197 more institutions
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Abstract
Lists of authors and their affiliations appear in the online version of the paper Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry 1 . We identified 65 new loci that are associated with overall breast cancer risk at P
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362Topics & keywords
Topics
Keywords
- Breast cancer
- Oncology
- Association (psychology)
- Medicine
- Genetics
- Biology
- Computational biology
- Cancer
UN Sustainable Development Goals
- Good health and well-being
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Funding
- GCGenome Canada
- MDMinistère du Développement Économique, de l’Innovation et de l’ExportationAwards: C1287/A10118, PSR-SIIRI-701, HEALTH-F2-2009-223175, 634935, C1287/A10710, U19 CA148065, C1287/A16563, 633784
- FDFondation du cancer du sein du QuébecAwards: C1287/A10710, HEALTH-F2-2009-223175, C1287/A10118, PSR-SIIRI-701, C1287/A16563, U19 CA148065, 634935, 633784
- GOGovernment of CanadaAwards: C1287/A10710, U19 CA148065, 634935, PSR-SIIRI-701, C1287/A10118, HEALTH-F2-2009-223175, C1287/A16563, 633784
- CRCancer Research UKAwards: 223175, U19 CA148065, C1287, 633784, 634935, A16563, HEALTH-F2-2009-223175, C1287/A10710, PSR-SIIRI-701, C1287/A16563, C1287/A10118
- ECEuropean CommissionAwards: U19 CA148065, 633784, C1287/A10118, C1287/A10710, 634935, C1287/A16563, PSR-SIIRI-701, HEALTH-F2-2009-223175, 223175
- MDMinistero dello Sviluppo Economico
- NINational Institutes of HealthAwards: U19 CA148065, 634935, 223175, 633784, PSR-SIIRI-701, U19 CA 148065, C1287/A16563, C1287/A10118, C1287/A10710, HEALTH-F2-2009-223175, X01HG007492
- CICanadian Institutes of Health ResearchAwards: C1287/A10710, C1287/A10118, C1287/A16563, PSR-SIIRI-701, 634935, HEALTH-F2-2009-223175, 633784, U19 CA148065, 223175
- MRMedical Research CouncilAward: MC_PC_14105
- NCNational Cancer InstituteAwards: C1287/A10710, PSR-SIIRI-701, HEALTH-F2-2009-223175, CA148065, 634935, C1287/A16563, C1287/A10118, U19 CA148065, 633784