reviewNeuroImageNov 4, 2017HYBRID OA

Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis

JFJoseph FirthBSBrendon StubbsDVDavy VancampfortFBFelipe Barreto SchuchJLJim Lagopoulos

Western Sydney University · University of Manchester · +9 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Hippocampal volume increase in response to aerobic exercise has been consistently observed in animal models. However, the evidence from human studies is equivocal. We undertook a systematic review to identify all controlled trials examining the effect of aerobic exercise on the hippocampal volumes in humans, and applied meta-analytic techniques to determine if aerobic exercise resulted in volumetric increases. We also sought to establish how volume changes differed in relation to unilateral measures of left/right hippocampal volume, and across the lifespan. A systematic search identified 4398 articles, of which 14 were eligible for inclusion in the primary analysis. A random-effects meta-analysis showed no…

Citation impact

509
total citations
FWCI
18.35
Percentile
100%
References
65
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Authors

7

Topics & keywords

Topics
Keywords
  • Aerobic exercise
  • Hippocampal formation
  • Meta-analysis
  • Psychology
  • Hippocampus
  • Physical medicine and rehabilitation
  • Medicine
  • Physical therapy
UN Sustainable Development Goals
  • Reduced inequalities
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