Identifying and Characterizing circRNA-Protein Interaction
Health Sciences Centre · Sunnybrook Research Institute · +5 more institutions
Abstract
Circular RNAs have been identified as naturally occurring RNAs that are highly represented in the eukaryotic transcriptome. Although a large number of circRNAs have been reported, circRNA functions remain largely unknown. CircRNAs can function as miRNA sponges, thereby reducing their ability to target mRNAs. We hypothesize that circRNAs may bind, store, sort, and sequester proteins to particular subcellular locations, and act as dynamic scaffolding molecules that modulate protein-protein interactions. Here, we review the biological implication and function of circRNA-protein interaction, and reveal a dynamic model of the interaction in various tissues, development stages and physiological conditions. Improved…
Citation impact
- FWCI
- 19.96
- Percentile
- 100%
- References
- 59
Authors
6- WWWilliam W. DuCorresponding
Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Sunnybrook Health Science Centre
- CZChao Zhang
Sunnybrook Research Institute, Health Sciences Centre, Sunnybrook Health Science Centre, University of Toronto
- WYWeining Yang
Sunnybrook Health Science Centre, Health Sciences Centre, Sunnybrook Research Institute
- TYTianqiao Yong
Guangdong Academy of Sciences, Institute of Microbiology
- FMFaryal Mehwish Awan
University of Toronto, Sunnybrook Research Institute, Health Sciences Centre, Sunnybrook Health Science Centre, National University of Sciences and Technology
Topics & keywords
- Chemistry
- Protein–protein interaction
- Computational biology
- Nanotechnology
- Biophysics
- Biology
- Biochemistry
- Materials science