The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy
University of Southern California · University of California, Los Angeles
Abstract
Epidemiologic studies have previously suggested that premenopausal females have reduced incidence of cardiovascular disease (CVD) when compared to age-matched males, and the incidence and severity of CVD increases postmenopause. The lower incidence of cardiovascular disease in women during reproductive age is attributed at least in part to estrogen (E2). E2 binds to the traditional E2 receptors (ERs), estrogen receptor alpha (ERα), and estrogen receptor beta (ERβ), as well as the more recently identified G-protein-coupled ER (GPR30), and can exert both genomic and non-genomic actions. This review summarizes the protective role of E2 and its receptors in the cardiovascular system and discusses its underlying…
Citation impact
- FWCI
- 30.38
- Percentile
- 100%
- References
- 142
Authors
6Topics & keywords
- Medicine
- Estrogen
- Estrogen receptor
- Aromatase
- Disease
- GPER
- Internal medicine
- Estrogen receptor alpha
- Good health and well-being