Surface Modified Ti 3 C 2 MXene Nanosheets for Tumor Targeting Photothermal/Photodynamic/Chemo Synergistic Therapy
Nanjing Tech University · Zhongda Hospital Southeast University · +1 more institution
Abstract
Ti3C2 MXene is a new two-dimensional material exhibiting a variety of novel properties including good photothermal effect, and the capability of Ti3C2 for multimodal tumor therapy is in urgent need of development. Herein, ultrathin Ti3C2 MXene nanosheets (∼100 nm) have been synthesized by supplying additive Al3+ to avoid Al loss and employed as a photothermal/photodynamic agent for cancer therapy. The as-obtained nanosheets exhibit outstanding mass extinction coefficient (28.6 Lg–1 cm–1 at 808 nm), superior photothermal conversion efficiency (∼58.3%), and effective singlet oxygen generation (1O2) upon 808 nm laser irradiation. Based on these Ti3C2 nanosheets, a multifunctional nanoplatform (Ti3C2-DOX) is…
Citation impact
- FWCI
- 19.75
- Percentile
- 100%
- References
- 52
Authors
10Topics & keywords
- Materials science
- Photothermal therapy
- Photodynamic therapy
- Surface modification
- Nanotechnology
- Chemical engineering
- Organic chemistry