Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
Université Toulouse III - Paul Sabatier · Institut National Polytechnique de Toulouse · +9 more institutions
Abstract
Oxidative stress is known to play an important role in the pathogenesis of a number of diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related neurodegenerative disease and the most common cause of dementia in the elderly. Histopathological hallmarks of AD are intracellular neurofibrillary tangles and extracellular formation of senile plaques composed of the amyloid-beta peptide (Aβ) in aggregated form along with metal-ions such as copper, iron or zinc. Redox active metal ions, as for example copper, can catalyze the production of Reactive Oxygen Species (ROS) when bound to the amyloid-β (Aβ). The ROS thus produced, in particular the hydroxyl radical which is the most…
Citation impact
- FWCI
- 89.09
- Percentile
- 100%
- References
- 219
Authors
6- CCClémence Cheignon
Université Toulouse III - Paul Sabatier, Institut National Polytechnique de Toulouse, Laboratoire de Chimie de Coordination
- MTMireia Tomas
Laboratoire de Chimie de Coordination, Université Toulouse III - Paul Sabatier, Institut National Polytechnique de Toulouse
- DBDominique Bonnefont‐Rousselot
Pitié-Salpêtrière Hospital, Assistance Publique – Hôpitaux de Paris, Délégation Paris 5, Université Paris Cité, Sorbonne Université, Unité de Technologies Chimiques et Biologiques pour la Santé
- PFPeter Faller
Institut de Chimie de Strasbourg, Centre National de la Recherche Scientifique
- CHChristelle Hureau
Institut National Polytechnique de Toulouse, Laboratoire de Chimie de Coordination, Université Toulouse III - Paul Sabatier
Topics & keywords
- Oxidative stress
- Senile plaques
- Reactive oxygen species
- Chemistry
- Peptide
- Oxidative phosphorylation
- Biochemistry
- Alzheimer's disease