Antiferromagnetic Pyrite as the Tumor Microenvironment‐Mediated Nanoplatform for Self‐Enhanced Tumor Imaging and Therapy
Chinese Academy of Sciences · Shanghai Institute of Ceramics · +4 more institutions
Abstract
Several decades of research have identified the specific tumor microenvironment (TME) to develop promising nanotheranostics, such as pH-sensitive imaging, acidity-sensitive starving therapy, and hydrogen peroxide-activated chemotherapy, etc. Herein, a novel TME-mediated nanoplatform employing antiferromagnetic pyrite nanocubes is presented, exploiting the intratumoral, overproduced peroxide for self-enhanced magnetic resonance imaging (MRI) and photothermal therapy (PTT)/chemodynamic therapy (CDT). Through the activation of excessive peroxide in the tumor microenvironment, pyrite can lead to in situ surface oxidation and generate hydroxyl radicals to kill tumor cells (i.e., CDT). The increase of the valence…
Citation impact
- FWCI
- 28.34
- Percentile
- 100%
- References
- 36
Authors
10- ZTZhongmin Tang
Chinese Academy of Sciences, Shanghai Institute of Ceramics, University of Chinese Academy of Sciences
- HZHuilin Zhang
Fudan University, Huashan Hospital, East China Normal University
- YLYanyan Liu
East China Normal University
- DNDalong Ni
Chinese Academy of Sciences, Shanghai Institute of Ceramics
- HZHua Zhang
Fudan University, Huashan Hospital, East China Normal University
Topics & keywords
- Materials science
- Tumor microenvironment
- Pyrite
- Nanotechnology
- Cancer therapy
- Cancer research
- Biophysics
- Tumor cells