The challenge of mapping the human connectome based on diffusion tractography

Maier‐Hein, Klaus; Neher, Peter; Houde, Jean-Christophe; Côté, Marc-Alexandre; Garyfallidis, Eleftherios; zhong, jinyu; Chamberland, Maxime; Yeh, Fang‐Cheng; Lin, Ying‐Chia; Ji, Qing; Reddick, Wilburn E.; Glass, John O.; Chen, David Qixiang; Feng, Yuanjing; Gao, Chengfeng; Wu, Ye; Ma, Jieyan; He, Renjie; Li, Qiang; Westin, Carl‐Fredrik; Deslauriers‐Gauthier, Samuel; González, J. Omar Ocegueda; Paquette, Michael; St‐Jean, Samuel; Girard, Gabriel; Rheault, François; Sidhu, Jasmeen; Tax, Chantal M. W.; Guo, Fenghua; Mesri, Hamed Y.; Dávid, Szabolcs; Froeling, Martijn; Heemskerk, Anneriet M.; Leemans, Alexander; Boré, Arnaud; Pinsard, Basile; Bedetti, Christophe; Desrosiers, Matthieu; Brambati, Simona M.; Doyon, Julien; Sarica, Alessia; Vasta, Roberta; Cerasa, Antonio; Quattrone, Aldo; Yeatman, Jason D.; Khan, Ali R.; Hodges, Wes; Alexander, Simon; Romascano, David; Baraković, Muhamed; Auría, Anna; Estéban, Oscar; Lemkaddem, Alia; Thiran, Jean‐Philippe; Çetingül, H. Ertan; Odry, Benjamin L.; Mailhé, Boris; Nadar, Mariappan S.; Pizzagalli, Fabrizio; Prasad, Gautam; Villalón‐Reina, Julio E.; Galvis, Justin; Thompson, Paul M.; Requejo, Francisco De Santiago; Laguna, Pedro Luque; Lacerda, Luís Miguel; Barrett, Rachel; Dell’Acqua, Flavio; Catani, Marco; Petit, Laurent; Caruyer, Emmanuel; Daducci, Alessandro; Dyrby, Tim B.; Holland‐Letz, Tim; Hilgetag, Claus C.; Stieltjes, Bram; Descoteaux, Maxime

doi:10.1038/s41467-017-01285-x

articleNature CommunicationsNov 1, 2017GOLD OA

The challenge of mapping the human connectome based on diffusion tractography

KMKlaus Maier‐Hein PNPeter Neher JHJean-Christophe Houde MCMarc-Alexandre Côté EGEleftherios Garyfallidis

German Cancer Research Center · Heidelberg University · +49 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent). However, the same tractograms contain many more invalid than valid bundles, and half of these invalid bundles occur systematically across research groups. Taken…

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Topics

Keywords

Connectome
Tractography
Diffusion MRI
Human Connectome Project
Connectomics
Computer science
Neuroscience
Diffusion

UN Sustainable Development Goals

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