Transition-Metal-Catalyzed Cross-Couplings through Carbene Migratory Insertion
Peking University · Beijing National Laboratory for Molecular Sciences
Abstract
Transition-metal-catalyzed cross-coupling reactions have been well-established as indispensable tools in modern organic synthesis. One of the major research goals in cross-coupling area is expanding the scope of the coupling partners. In the past decade, diazo compounds (or their precursors N-tosylhydrazones) have emerged as nucleophilic cross-coupling partners in C-C single bond or C═C double bond formations in transition-metal-catalyzed reactions. This type of coupling reaction involves the following general steps. First, the organometallic species is generated by various processes, including oxidative addition, transmetalation, cyclization, C-C bond cleavage, and C-H bond activation. Subsequently, the…
Citation impact
- FWCI
- 49.85
- Percentile
- 100%
- References
- 480
Authors
3Topics & keywords
- Diazo
- Carbene
- Chemistry
- Transmetalation
- Migratory insertion
- Nucleophile
- Catalysis
- Transition metal