Comprehensive analysis of normal adjacent to tumor transcriptomes
University of California, San Francisco · Stanford Medicine · +3 more institutions
Abstract
Histologically normal tissue adjacent to the tumor (NAT) is commonly used as a control in cancer studies. However, little is known about the transcriptomic profile of NAT, how it is influenced by the tumor, and how the profile compares with non-tumor-bearing tissues. Here, we integrate data from the Genotype-Tissue Expression project and The Cancer Genome Atlas to comprehensively analyze the transcriptomes of healthy, NAT, and tumor tissues in 6506 samples across eight tissues and corresponding tumor types. Our analysis shows that NAT presents a unique intermediate state between healthy and tumor. Differential gene expression and protein-protein interaction analyses reveal altered pathways shared among NATs…
Citation impact
- FWCI
- 13.58
- Percentile
- 100%
- References
- 64
Authors
9- DADvir AranCorresponding
University of California, San Francisco
- RCRoman Camarda
University of California, San Francisco
- JIJustin I. Odegaard
Stanford Medicine, Stanford University
- HPHarikrishna Paik
University of California, San Francisco, Korea Institute of Science & Technology Information
- BOBoris Oskotsky
University of California, San Francisco
Topics & keywords
- Transcriptome
- Nat
- Biology
- Gene
- Cancer
- Gene expression
- Computational biology
- Cancer research
- Good health and well-being