Abstract
Vitamin C is an essential micronutrient for humans, with pleiotropic functions related to its ability to donate electrons. It is a potent antioxidant and a cofactor for a family of biosynthetic and gene regulatory enzymes. Vitamin C contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system. Vitamin C supports epithelial barrier function against pathogens and promotes the oxidant scavenging activity of the skin, thereby potentially protecting against environmental oxidative stress. Vitamin C accumulates in phagocytic cells, such as neutrophils, and can enhance chemotaxis, phagocytosis, generation of reactive oxygen species, and ultimately microbial…
Citation impact
1,961
total citations
- FWCI
- 63.60
- Percentile
- 100%
- References
- 279
Citations per year
Authors
2Topics & keywords
Topics
Keywords
- Immune system
- Inflammation
- Vitamin
- Biology
- Respiratory burst
- Immunology
- Vitamin C
- Innate immune system
UN Sustainable Development Goals
- Zero hunger
No related works found for this paper.