Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

Gopalakrishnan, Vancheswaran; Spencer, C. N.; Nezi, Luigi; Reuben, Alexandre; Andrews, Miles C.; Karpinets, Tatiana V.; Prieto, Peter A.; Vicente, Diego; Hoffman, Kristi L.; Wei, Spencer C.; Cogdill, Alexandria P.; Zhao, L.; Hudgens, Courtney W.; Hutchinson, Diane S.; Manzo, Teresa; Macêdo, Mariana Petaccia de; Cotechini, Tiziana; Kumar, Tapsi; Chen, W. S.; Reddy, Sangeetha M.; Szczepaniak‐Sloane, Robert; Galloway-Peña, Jessica; Jiang, Hong; Chen, P. L.; Shpall, Elizabeth J.; Rezvani, Katayoun; Alousi, Amin M.; Chemaly, Roy F.; Shelburne, Samuel A.; Vence, Luis M.; Okhuysen, Pablo C.; Jensen, V. Behrana; Swennes, Alton G.; McAllister, Florencia; Riquelme, Erick; Zhang, Yexi; Chatelier, Emmanuelle Le; Zitvogel, Laurence; Pons, Nicolas; Austin-Breneman, Jacob L.; Haydu, Lauren E.; Burton, Elizabeth M.; Gardner, Julie M.; Sirmans, Elizabeth; Hu, Jiemiao; Lazar, Alexander J.; Tsujikawa, Takahiro; Diab, Adi; Tawbi, Hussein A.; Glitza, Isabella C.; Hwu, Wen-Jen; Patel, Sapna P.; Woodman, Scott E.; Amaria, Rodabe N.; Davies, Michael A.; Gershenwald, Jeffrey E.; Hwu, Patrick; Lee, J. E.; Zhang, J.; Coussens, Lisa M.; Cooper, Zachary A.; Futreal, P. Andrew; Daniel, Carrie R.; Ajami, Nadim J.; Petrosino, Joseph F.; Tetzlaff, Michael T.; Sharma, Padmanee; Allison, James P.; Jenq, Robert R.; Wargo, Jennifer A.

doi:10.1126/science.aan4236

articleScienceNov 2, 2017GREEN OA

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

VGVancheswaran GopalakrishnanCNC. N. SpencerLNLuigi Nezi ARAlexandre Reuben MCMiles C. Andrews

The University of Texas MD Anderson Cancer Center · The University of Texas Health Science Center at Houston · +4 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Good bacteria help fight cancer Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy et al. show that antibiotic consumption is associated with poor response to immunotherapeutic PD-1 blockade. They profiled samples from patients with lung and kidney cancers and found that nonresponding patients had low levels of the bacterium Akkermansia muciniphila . Oral supplementation of the bacteria to antibiotic-treated mice restored the response to immunotherapy. Matson et al. and Gopalakrishnan et al. studied melanoma patients receiving PD-1 blockade and found a greater abundance of “good” bacteria in the guts of responding patients. Nonresponders had an…

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70

VG
Vancheswaran GopalakrishnanCorresponding
The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston
CN
C. N. SpencerCorresponding
The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston
LN
Luigi NeziCorresponding
The University of Texas MD Anderson Cancer Center
AR
Alexandre Reuben
The University of Texas MD Anderson Cancer Center
MC
Miles C. Andrews
The University of Texas MD Anderson Cancer Center

Topics & keywords

Topics

Keywords

Microbiome
Immunotherapy
Melanoma
Gut microbiome
Tumor immunology
Computational biology
Immunology
Biology

UN Sustainable Development Goals

Good health and well-being

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