Ectopic colonization of oral bacteria in the intestine drives T H 1 cell induction and inflammation
Keio University · RIKEN Center for Integrative Medical Sciences · +15 more institutions
Abstract
Gut reasons to brush your teeth Some gut conditions, such as inflammatory bowel disease (IBD), ulcerative colitis, and Crohn's disease (CD), are associated with imbalances in the gut microbe community. The causes of these intractable diseases have been difficult to discern. Atarashi et al. took samples from the mouths of IBD and CD patients and inoculated the extracted bacteria into germ-free mice (see the Perspective by Cao). Some of the inoculated mice showed strong proliferation of T helper 1 cells associated with the establishment of oral Klebsiella species in the colon. Klebsiella can be resistant to multiple antibiotics and are able to replace normal colon microbes after antibiotic therapy. Now we know…
Citation impact
- FWCI
- 22.87
- Percentile
- 100%
- References
- 40
Authors
26- KAKoji Atarashi
Keio University, RIKEN Center for Integrative Medical Sciences
- WSWataru Suda
Waseda University, Keio University, The University of Tokyo
- CLChengwei Luo
Broad Institute, Harvard University, Massachusetts General Hospital
- TKTakaaki Kawaguchi
Keio University, RIKEN Center for Integrative Medical Sciences
- IMIori Motoo
RIKEN Center for Integrative Medical Sciences
Topics & keywords
- Colonization
- Ulcerative colitis
- Bacteria
- Antibiotics
- Inflammatory bowel disease
- Inflammation
- Disease
- Microbiology