reviewChemical ReviewsOct 19, 2017Closed access

Nanotechnology for Multimodal Synergistic Cancer Therapy

National Institutes of Health · Shenzhen University · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic potential of treatment. Therefore, the current trend in clinical research has gradually shifted from a focus on monotherapy to combination therapy for enhanced treatment efficacy. More importantly, the cooperative enhancement interactions between several types of monotherapy contribute to the naissance of multimodal synergistic therapy, which results in remarkable superadditive (namely "1 + 1 > 2") effects, stronger than any single therapy or their theoretical combination. In this review, state-of-the-art studies concerning recent advances in nanotechnology-mediated multimodal synergistic therapy will be systematically…

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