High grade serous ovarian carcinomas originate in the fallopian tube

High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and copy number analyses of laser capture microdissected fallopian tube lesions (p53 signatures, serous tubal intraepithelial carcinomas (STICs), and fallopian tube carcinomas), ovarian cancers, and metastases from nine patients. The majority of tumor-specific alterations in ovarian cancers were present in STICs, including those affecting TP53, BRCA1, BRCA2 or PTEN. Evolutionary analyses reveal that p53 signatures and STICs…

• UD
  U.S. Department of Defense
• AA
  American Association for Cancer Research

  Award: SU2C-AACR-DT1415
• DM
  Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

  Award: CA121113
• EI
  Entertainment Industry Foundation
• HT
  Honorable Tina Brozman Foundation
• FD
  Fondation de France
• NI
  National Institutes of Health

  Awards: CA006973, CA121113
• SU
  Stand Up To Cancer

  Award: SU2C-AACR-DT1415