Pathways of cellular proteostasis in aging and disease
Max Planck Institute of Biochemistry
Indexed incrossrefpubmed
Abstract
Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein synthesis, folding, conformational maintenance, and degradation. A complex and adaptive proteostasis network coordinates these processes with molecular chaperones of different classes and their regulators functioning as major players. This network serves to ensure that cells have the proteins they need while minimizing misfolding or aggregation events that are hallmarks of age-associated proteinopathies, including neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. It is now clear that the capacity of cells to maintain proteostasis undergoes a decline during aging, rendering the organism…
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809
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Authors
3Topics & keywords
Topics
Keywords
- Proteostasis
- Neurodegeneration
- Protein folding
- Biology
- Neuroscience
- Disease
- Protein aggregation
- Cell biology
UN Sustainable Development Goals
- Good health and well-being
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