Emerging functions of the EGFR in cancer
IFOM · Department of Medical Sciences · +2 more institutions
Abstract
The physiological function of the epidermal growth factor receptor (EGFR) is to regulate epithelial tissue development and homeostasis. In pathological settings, mostly in lung and breast cancer and in glioblastoma, the EGFR is a driver of tumorigenesis. Inappropriate activation of the EGFR in cancer mainly results from amplification and point mutations at the genomic locus, but transcriptional upregulation or ligand overproduction due to autocrine/paracrine mechanisms has also been described. Moreover, the EGFR is increasingly recognized as a biomarker of resistance in tumors, as its amplification or secondary mutations have been found to arise under drug pressure. This evidence, in addition to the prominent…
Citation impact
- FWCI
- 50.66
- Percentile
- 100%
- References
- 172
Authors
3Topics & keywords
- Cancer research
- Cancer
- Medicine
- Computational biology
- Biology
- Chemistry
- Internal medicine