reviewBloodNov 8, 2017BRONZE OA

CTLA-4: a moving target in immunotherapy

BRBehzad RowshanravanNHNeil HallidayDMDavid M. Sansom

The Royal Free Hospital · University College London

PubMed
Indexed incrossrefpubmed

Abstract

Abstract CD28 and CTLA-4 are members of a family of immunoglobulin-related receptors that are responsible for various aspects of T-cell immune regulation. The family includes CD28, CTLA-4, and ICOS as well as other proteins, including PD-1, BTLA, and TIGIT. These receptors have both stimulatory (CD28, ICOS) and inhibitory roles (CTLA-4, PD-1, BTLA, and TIGIT) in T-cell function. Increasingly, these pathways are targeted as part of immune modulatory strategies to treat cancers, referred to generically as immune checkpoint blockade, and conversely to treat autoimmunity and CTLA-4 deficiency. Here, we focus on the biology of the CD28/CTLA-4 pathway as a framework for understanding the impacts of therapeutic…

Citation impact

1,205
total citations
FWCI
21.35
Percentile
100%
References
146
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • TIGIT
  • BTLA
  • CTLA-4
  • CD28
  • Immunology
  • Autoimmunity
  • Immune system
  • T cell
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding