miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions

MicroRNAs (miRNAs) are small non-coding RNAs of ∼ 22 nucleotides that are involved in negative regulation of mRNA at the post-transcriptional level. Previously, we developed miRTarBase which provides information about experimentally validated miRNA-target interactions (MTIs). Here, we describe an updated database containing 422 517 curated MTIs from 4076 miRNAs and 23 054 target genes collected from over 8500 articles. The number of MTIs curated by strong evidence has increased ∼1.4-fold since the last update in 2016. In this updated version, target sites validated by reporter assay that are available in the literature can be downloaded. The target site sequence can extract new features for analysis via a…

• SE
  Shanghai Educational Development Foundation
• MO
  Ministry of Science and Technology, Taiwan

  Awards: MOST 106-, MOST 103-2628-B-009-001-MY3, MOST 106-2319-B-400-001, MOST 106-2633-B-009-001, 106-2319-B-400-001, 106-2633-B-009-001, MOST 106, MOST 106-2627-M-009-002
• NC
  National Chiao Tung University