reviewFrontiers in PhysiologyNov 8, 2017GOLD OA

Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications

GCGianfranca CartaEMElisabetta MurruSBSebastiano BanniCMClaudia Manca

University of Cagliari

PubMed
Indexed incrossrefdoajpubmed

Abstract

Palmitic acid (PA) has been for long time negatively depicted for its putative detrimental health effects, shadowing its multiple crucial physiological activities. PA is the most common saturated fatty acid accounting for 20-30% of total fatty acids in the human body and can be provided in the diet or synthesized endogenously via de novo lipogenesis (DNL). PA tissue content seems to be controlled around a well-defined concentration, and changes in its intake do not influence significantly its tissue concentration because the exogenous source is counterbalanced by PA endogenous biosynthesis. Particular physiopathological conditions and nutritional factors may strongly induce DNL, resulting in increased tissue…

Citation impact

787
total citations
FWCI
19.54
Percentile
100%
References
206
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Palmitoylethanolamide
  • Lipogenesis
  • Homeostasis
  • Polyunsaturated fatty acid
  • Internal medicine
  • Endocrinology
  • Metabolism
  • Palmitic acid
UN Sustainable Development Goals
  • Zero hunger
No related works found for this paper.

Funding