Chemical Biology of H 2 S Signaling through Persulfidation

Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for understanding the physiological and pharmacological effects of H2S. Due to the inherent instability of persulfides, their chemistry is understudied. In this review, we discuss the biologically relevant chemistry of H2S and the enzymatic routes for its production and oxidation. We cover the chemical biology of persulfides and the chemical probes for detecting them. We conclude by discussing the roles ascribed to protein persulfidation in cell signaling pathways.

• AN
  Agence Nationale de la Recherche
• CN
  Centre National de la Recherche Scientifique
• CS
  Comisión Sectorial de Investigación Científica
• NH
  National Heart, Lung, and Blood Institute

  Award: HL58984
• NI
  National Institute of General Medical Sciences

  Award: GM112455