Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation

Photobiomodulation (PBM) involves the use of red or near-infrared light at low power densities to produce a beneficial effect on cells or tissues. PBM therapy is used to reduce pain, inflammation, edema, and to regenerate damaged tissues such as wounds, bones, and tendons. The primary site of light absorption in mammalian cells has been identified as the mitochondria and, more specifically, cytochrome c oxidase (CCO). It is hypothesized that inhibitory nitric oxide can be dissociated from CCO, thus restoring electron transport and increasing mitochondrial membrane potential. Another mechanism involves activation of light or heat-gated ion channels. This review will cover the redox signaling that occurs in PBM…

• NI
  National Institutes of Health

  Awards: R01AI050875, R21AI121700
• AF
  Air Force Office of Scientific Research

  Award: FA9550‐13‐1‐0068
• MR
  Medical Research and Materiel Command

  Award: W81XWH‐13‐2‐0067