Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis
University of Bristol · National Institute for Health and Care Research · +5 more institutions
Abstract
Abstract Objective To compare the efficacy, safety, and cost effectiveness of direct acting oral anticoagulants (DOACs) for patients with atrial fibrillation. Design Systematic review, network meta-analysis, and cost effectiveness analysis. Data sources Medline, PreMedline, Embase, and The Cochrane Library. Eligibility criteria for selecting studies Published randomised trials evaluating the use of a DOAC, vitamin K antagonist, or antiplatelet drug for prevention of stroke in patients with atrial fibrillation. Results 23 randomised trials involving 94 656 patients were analysed: 13 compared a DOAC with warfarin dosed to achieve a target INR of 2.0-3.0. Apixaban 5 mg twice daily (odds ratio 0.79, 95% confidence…
Citation impact
- FWCI
- 37.02
- Percentile
- 100%
- References
- 39
Authors
18- JAJosé A López-LópezCorresponding
University of Bristol
- JAJonathan A C Sterne
National Institute for Health and Care Research, University of Bristol
- HTHoward Thom
University of Bristol
- JPJulian P. T. Higgins
National Institute for Health and Care Research, University of Bristol
- ADAroon D. Hingorani
University College London
Topics & keywords
- Meta-analysis
- Atrial fibrillation
- Stroke (engine)
- Medicine
- Intensive care medicine
- Cardiology
- Internal medicine
- Engineering
- Good health and well-being