The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration
University of Ottawa · Ottawa Hospital Research Institute · +1 more institution
Abstract
The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are members of the basic helix-loop-helix family of transcription factors that control the determination and differentiation of skeletal muscle cells during embryogenesis and postnatal myogenesis. The dynamics of their temporal and spatial expression as well as their biochemical properties have allowed the identification of a precise and hierarchical relationship between the four MRFs. This relationship establishes the myogenic lineage as well as the maintenance of the terminal myogenic phenotype. The application of genome-wide technologies has provided important new information as to how the MRFs function to activate muscle gene expression.…
Citation impact
- FWCI
- 13.46
- Percentile
- 100%
- References
- 90
Authors
4- JMJ. Manuel Hernández‐Hernández
University of Ottawa, Ottawa Hospital Research Institute, Ottawa Hospital
- EGEstela G. García-González
Ottawa Hospital, Ottawa Hospital Research Institute, University of Ottawa
- CBCaroline Brun
Ottawa Hospital Research Institute, Ottawa Hospital, University of Ottawa
- MAMichael A. RudnickiCorresponding
University of Ottawa, Ottawa Hospital, Ottawa Hospital Research Institute
Topics & keywords
- MYF5
- MyoD
- Myogenin
- Myogenesis
- Myogenic regulatory factors
- Biology
- Transcription factor
- Cell biology