The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database
European Bioinformatics Institute · Wellcome Trust · +1 more institution
Abstract
The MEROPS database (http://www.ebi.ac.uk/merops/) is an integrated source of information about peptidases, their substrates and inhibitors. The hierarchical classification is: protein-species, family, clan, with an identifier at each level. The MEROPS website moved to the EMBL-EBI in 2017, requiring refactoring of the code-base and services provided. The interface to sequence searching has changed and the MEROPS protein sequence libraries can be searched at the EMBL-EBI with HMMER, FastA and BLASTP. Cross-references have been established between MEROPS and the PANTHER database at both the family and protein-species level, which will help to improve curation and coverage between the resources. Because of the…
Citation impact
- FWCI
- 52.20
- Percentile
- 100%
- References
- 30
Authors
6- NDNeil D. RawlingsCorresponding
European Bioinformatics Institute, Wellcome Trust
- AJA. John Barrett
European Bioinformatics Institute, Wellcome Trust
- PDPaul D. Thomas
University of Southern California
- XHXiaosong Huang
University of Southern California
- ABAlex Bateman
European Bioinformatics Institute, Wellcome Trust
Topics & keywords
- Biology
- Proteome
- Database
- Computational biology
- Bioinformatics