Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species

Reactive oxygen species (ROS) are produced by living cells as normal cellular metabolic byproduct. Under excessive stress conditions, cells will produce numerous ROS, and the living organisms eventually evolve series of response mechanisms to adapt to the ROS exposure as well as utilize it as the signaling molecules. ROS molecules would trigger oxidative stress in a feedback mechanism involving many biological processes, such as apoptosis, necrosis and autophagy. Growing evidences have suggested that ROS play a critical role as the signaling molecules throughout the entire cell death pathway. Overwhelming production of ROS can destroy organelles structure and bio-molecules, which lead to inflammatory response…

• NN
  National Natural Science Foundation of China

  Awards: 31722054, 31528018, B16044, 31472101, 31722054, 31472101 and 31528018
• HE
  Higher Education Discipline Innovation Project

  Award: B16044
• NK
  National Key Research and Development Program of China

  Awards: 2017YFD0500501, 2013CB117301, B16044, 201403047