articleDiabetesNov 13, 2017Closed access

Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue

HZHui ZhaoQSQianwen ShangZPZhenzhen PanYBYang BaiZLZequn Li

Shandong University

PubMed
Indexed incrossrefpubmed

Abstract

Adipose-derived stem cells (ADSCs) play critical roles in controlling obesity-associated inflammation and metabolic disorders. Exosomes from ADSCs exert protective effects in several diseases, but their roles in obesity and related pathological conditions remain unclear. In this study, we showed that treatment of obese mice with ADSC-derived exosomes facilitated their metabolic homeostasis, including improved insulin sensitivity (27.8% improvement), reduced obesity, and alleviated hepatic steatosis. ADSC-derived exosomes drove alternatively activated M2 macrophage polarization, inflammation reduction, and beiging in white adipose tissue (WAT) of diet-induced obese mice. Mechanistically, exosomes from ADSCs…

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Authors

10

Topics & keywords

Topics
Keywords
  • Adipose tissue
  • White adipose tissue
  • Microvesicles
  • Inflammation
  • Endocrinology
  • Internal medicine
  • Adipose tissue macrophages
  • Obesity
UN Sustainable Development Goals
  • Good health and well-being
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